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Issue 19, 2009
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Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

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Abstract

The penetration of anthraquinones and their platinum complexes into cancer cell spheroids reveals that they model well the distribution of such compounds in solid tumours and that the proportion of the compound that accumulates deep in the spheroid is inversely related to the rate of cellular uptake which is affected by the charge of the compound.

Graphical abstract: Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

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Publication details

The article was received on 04 Feb 2009, accepted on 13 Mar 2009 and first published on 23 Mar 2009


Article type: Communication
DOI: 10.1039/B902415H
Citation: Chem. Commun., 2009,0, 2673-2675
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    Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

    N. S. Bryce, J. Z. Zhang, R. M. Whan, N. Yamamoto and T. W. Hambley, Chem. Commun., 2009, 0, 2673
    DOI: 10.1039/B902415H

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