Advances in gene delivery through molecular design of cationic lipids

Santanu Bhattacharya; Avinash Bajaj

doi:10.1039/B900666B

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Chemical Communications

Issue 31, 2009

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Advances in gene delivery through molecular design of cationic lipids

Santanu Bhattacharya and Avinash Bajaj

Chem. Commun., 2009, 4632-4656

DOI: 10.1039/B900666B
Received 12 Jan 2009, Accepted 13 May 2009
First published on the web 03 Jul 2009

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This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure–activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

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Chemical Communications

Advances in gene delivery through molecular design of cationic lipids

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