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Issue 15, 2009
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A conformational transition in the structure of a 2′-thiomethyl-modified DNA visualized at high resolution

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Abstract

Crystal structures of A-form and B-form DNA duplexes containing 2′-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3′-endo pucker, illustrating that the replacement of electronegative oxygen at the 2′-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.

Graphical abstract: A conformational transition in the structure of a 2′-thiomethyl-modified DNA visualized at high resolution

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Publication details

The article was received on 18 Dec 2008, accepted on 30 Jan 2009 and first published on 26 Feb 2009


Article type: Communication
DOI: 10.1039/B822781K
Citation: Chem. Commun., 2009, 2017-2019
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    A conformational transition in the structure of a 2′-thiomethyl-modified DNA visualized at high resolution

    P. S. Pallan, T. P. Prakash, F. Li, R. L. Eoff, M. Manoharan and M. Egli, Chem. Commun., 2009, 2017
    DOI: 10.1039/B822781K

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