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Issue 14, 2009
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The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

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Abstract

The double Sonogashira coupling of diiodoparacyclophanes with alkynes proceeded to give planarly chiral dialkynylparacyclophanes; a chiral Pd catalyst, which was prepared in situ from PdCl2(CH3CN)2 and Taniaphos, realized the first asymmetric Sonogashira coupling with up to ca. 80% ee.

Graphical abstract: The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

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Publication details

The article was received on 24 Oct 2008, accepted on 14 Jan 2009 and first published on 24 Feb 2009


Article type: Communication
DOI: 10.1039/B818904H
Citation: Chem. Commun., 2009, 1870-1872
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    The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

    K. Kanda, T. Koike, K. Endo and T. Shibata, Chem. Commun., 2009, 1870
    DOI: 10.1039/B818904H

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