Hybrid micro-/nano-silica architectures made of bacterial-body-templated silica shell attached with fimbriae-templated silica nanotubes were prepared by using living fimbriaed bacteria E. Coli TG1 as templates, which can function as individual bioreactors to catalyze the hydrolysis of 4-nitrophenyl-β-D-galactopyranoside to form p-nitrophenol due to the presence of an intracellular enzyme.