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Issue 18, 2009
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The discovery of antibacterial agents using diversity-oriented synthesis

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Abstract

The emergence and increasing prevalence of multi-drug resistance bacterial strains represents a clear and present danger to the standard of human healthcare as we know it. The systematic study of modulating biological systems using small molecules (so-called chemical genetics) offers a potentially fruitful means of discovering critically needed new antibacterial agents. Crucial to the success of this approach is the ready availability of functionally diverse small molecule collections. In this feature article we focus upon the use of a diversity-oriented synthesis (DOS) approach for the efficient generation of such compound collections, and discuss the utility of DOS for the discovery of new antibacterial agents.

Graphical abstract: The discovery of antibacterial agents using diversity-oriented synthesis

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Publication details

The article was received on 25 Sep 2008, accepted on 24 Feb 2009 and first published on 01 Apr 2009


Article type: Feature Article
DOI: 10.1039/B816852K
Citation: Chem. Commun., 2009,0, 2446-2462
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    The discovery of antibacterial agents using diversity-oriented synthesis

    W. R. J. D. Galloway, A. Bender, M. Welch and D. R. Spring, Chem. Commun., 2009, 0, 2446
    DOI: 10.1039/B816852K

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