Issue 42, 2009
From the journal:

Chemical Communications

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation†

Keiichi Hattori,a   Tomoya Hirohama,a   Shuhei Imoto,a   Shuhei Kusanoa  and  Fumi Nagatsugi*a  

* Corresponding authors

a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi, Japan
E-mail: nagatugi@tagen.tohoku.ac.jp
Fax: 001-81-22-(217)-5633
Tel: 001-81-22-(217)-5633

Abstract

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

Graphical abstract: Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

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Article information

DOI
https://doi.org/10.1039/B915381K
Article type
Communication
Submitted
05 Aug 2009
Accepted
26 Aug 2009
First published
24 Sep 2009

Chem. Commun., 2009, 6463-6465

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Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

K. Hattori, T. Hirohama, S. Imoto, S. Kusano and F. Nagatsugi, Chem. Commun., 2009, 6463 DOI: 10.1039/B915381K

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