Issue 45, 2009
From the journal:

Chemical Communications

A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase†

Xiahong Xu,a   Zhou Nie,*a   Jinhua Chen,*a   Yingchun Fu,b   Wang Li,a   Qinpeng Shena  and  Shouzhuo Yaoab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: niezhou.hnu@gmail.com, chenjinhua@hnu.cn
Fax: +86-731-88821848

b Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P. R. China

Abstract

A novel label-free electrochemical strategy for monitoring the activity and inhibition of protein kinase is developed, based on the linkage between the phosphorylated peptide and DNA functionalized Au nanoparticles (DNA–AuNPs) by Zr4+ and the chronocoulometric response of [Ru(NH3)6]3+ absorbed on the DNA–AuNPs.

Graphical abstract: A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase

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Article information

DOI
https://doi.org/10.1039/B913943E
Article type
Communication
Submitted
13 Jul 2009
Accepted
08 Oct 2009
First published
16 Oct 2009

Chem. Commun., 2009, 6946-6948

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A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase

X. Xu, Z. Nie, J. Chen, Y. Fu, W. Li, Q. Shen and S. Yao, Chem. Commun., 2009, 6946 DOI: 10.1039/B913943E

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