Issue 28, 2009

Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

Abstract

We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an attractive route to synthesize a series of α(2,8)-linked oligosialic acids and their thioanalogs in one step.

Graphical abstract: Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

Supplementary files

Article information

Article type
Communication
Submitted
05 May 2009
Accepted
01 Jun 2009
First published
19 Jun 2009

Chem. Commun., 2009, 4233-4235

Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

P. Zhang, A. J. Zuccolo, W. Li, R. Blake Zheng and C. Ling, Chem. Commun., 2009, 4233 DOI: 10.1039/B908933K

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