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Issue 3, 2009
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Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(II) ions

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Abstract

We report that the hydrogen-bonding pattern in a molecular beacon can be replaced by metal-dependent pairs of Hg2+ and DNA thymine (T) bases. A molecular beacon based on T–Hg2+–T exhibits a lower background signal and higher thermostability than regular molecular beacons.

Graphical abstract: Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions

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Publication details

The article was received on 23 Sep 2008, accepted on 30 Oct 2008 and first published on 20 Nov 2008


Article type: Communication
DOI: 10.1039/B816638B
Citation: Chem. Commun., 2009, 322-324
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    Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(II) ions

    R. Yang, J. Jin, L. Long, Y. Wang, H. Wang and W. Tan, Chem. Commun., 2009, 322
    DOI: 10.1039/B816638B

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