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Issue 9, 2009
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Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs

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Abstract

A disposable microfluidic device was constructed by conveniently integrating one poly(methyl methacrylate) board with four reservoirs and one fractured fused-silica capillary with 50 µm i.d. and 7.5 cm total length on a printed circuit board for applying sampling and separation voltages. The disposable microfluidic device combined with a home-made ultraviolet workstation could be conveniently used for efficient screening and quantitative detection of µg mL−1 illicit drugs. Using eight illicit drugs as models, they could be baseline-separated within 240 s with the separation efficiency up to 600 047 plates m−1 at the designed device. The novel device and proposed protocol were successfully used to screen illicit drugs in human urine. This work presented a simple and low-cost method to fabricate the microfluidic device and provided a powerful way for sensitive and specific multi-screening of different drugs with high resolution, fast separation and low-cost.

Graphical abstract: Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs

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Publication details

The article was received on 31 Mar 2009, accepted on 17 Jun 2009 and first published on 13 Jul 2009


Article type: Paper
DOI: 10.1039/B906434F
Citation: Analyst, 2009,134, 1834-1839
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    Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs

    W. Qiang, C. Zhai, J. Lei, C. Song, D. Zhang, J. Sheng and H. Ju, Analyst, 2009, 134, 1834
    DOI: 10.1039/B906434F

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