Jump to main content
Jump to site search

Issue 9, 2009
Previous Article Next Article

Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy

Author affiliations

Abstract

The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids of silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due to steric repulsion between polymer-modified surfaces, the stability of the nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At the same time, the PEG coating remains sufficiently permeable to allow surface-enhanced Raman scattering (SERS) from micromolar concentrations of small molecules such as the anticancer drug mitoxantrone (MTX). The enhancement efficiency of the hot spot-free Ag-PEG was compared to that of citrate-stabilized Ag colloids used after pre-aggregation. The potential of the polymer-stabilized colloids developed in this study is discussed in terms of bioanalytical applications of SERS spectroscopy.

Graphical abstract: Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy

Back to tab navigation

Publication details

The article was received on 23 Mar 2009, accepted on 16 Jun 2009 and first published on 06 Jul 2009


Article type: Paper
DOI: 10.1039/B905694G
Citation: Analyst, 2009,134, 1868-1872
  •   Request permissions

    Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy

    A. Shkilnyy, M. Soucé, P. Dubois, F. Warmont, M. Saboungi and I. Chourpa, Analyst, 2009, 134, 1868
    DOI: 10.1039/B905694G

Search articles by author

Spotlight

Advertisements