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Issue 6, 2009
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Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging

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Abstract

We report the ability of infrared micro-spectral imaging, coupled with completely unsupervised methods of multivariate statistical analysis, to accurately reproduce the histological architecture of axillary lymph nodes and detect metastatic breast cancer cells. The acquisition of spectral data from tissue embedded in paraffin provided spectra free of dispersive artefacts that may be observed for infrared microscopic measurements using a ‘reflection/absorption’ methodology. As a consequence, superior tissue classification and identification of cellular abnormality unattainable for deparaffinised tissue was achieved.

Graphical abstract: Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging

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Publication details

The article was received on 26 Nov 2008, accepted on 04 Mar 2009 and first published on 01 Apr 2009


Article type: Paper
DOI: 10.1039/B821166C
Citation: Analyst, 2009,134, 1067-1076
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    Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging

    B. Bird, K. Bedrossian, N. Laver, M. Miljković, M. J. Romeo and M. Diem, Analyst, 2009, 134, 1067
    DOI: 10.1039/B821166C

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