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Issue 3, 2009
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Selective detection of dopamine using a combined permselective film of electropolymerized (poly-tyramine and poly-pyrrole-1-propionic acid) on a boron-doped diamond electrode

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Abstract

An effective and robust electrochemical approach has been developed for selective detection of dopamine in the presence of 3,4-dihydroxyphenylalanine (L-DOPA), ascorbic acid, uric acid and other dopamine metabolites. A ‘layer-by-layer’ film of tyramine and pyrrole-1-propionic acid (PPA) was formed by subsequent electropolymerization on a boron-doped diamond (BDD) electrode with an overall thickness of ∼33 nm as estimated by AFM. The formation of the electropolymerized homogeneous film was also confirmed by SEM and Raman spectroscopy. The modified BDD electrode exhibited rapid response to dopamine within 6 s and a detection limit of 50 nM with excellent reproducibility. The stable electropolymerized film was capable of excluding electroactive interference from 20 µM L-DOPA, 20 µM 3,4-dihydroxyphenylacetic acid (DOPAC), and ascorbic and uric acids at normal physiological conditions (100 µM each). The modified electrode could be used for several repeated analyses of dopamine at 5 µM, without noticeable surface fouling. A plausible mechanism for permselectivity was suggested and supported by pertinent experimental data.

Graphical abstract: Selective detection of dopamine using a combined permselective film of electropolymerized (poly-tyramine and poly-pyrrole-1-propionic acid) on a boron-doped diamond electrode

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Publication details

The article was received on 18 Aug 2008, accepted on 31 Oct 2008 and first published on 05 Dec 2008


Article type: Paper
DOI: 10.1039/B814317J
Citation: Analyst, 2009,134, 519-527
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    Selective detection of dopamine using a combined permselective film of electropolymerized (poly-tyramine and poly-pyrrole-1-propionic acid) on a boron-doped diamond electrode

    F. Shang, Y. Liu, S. Hrapovic, J. D. Glennon and J. H. T. Luong, Analyst, 2009, 134, 519
    DOI: 10.1039/B814317J

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