Production and performance of biomaterials containing RGD peptides

Lynne Perlin; Sheila MacNeil; Stephen Rimmer

doi:10.1039/B801646A

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Soft Matter

Issue 12, 2008

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Production and performance of biomaterials containing RGD peptides

Lynne Perlin , Sheila MacNeil and Stephen Rimmer

Soft Matter, 2008, 4, 2331-2349

DOI: 10.1039/B801646A
Received 30 Jan 2008, Accepted 16 Jul 2008
First published on the web 19 Sep 2008

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The arginine-glycine-aspartic acid (RGD) sequence binds to key cell membrane structures within the integrin family. These sequences are found on several extracellular proteins that have roles in cell adhesion. Therefore, it is not surprising that with the advent of the field of tissue engineering a large amount of work has been carried out on materials functionalised with a wide variety of RGD-containing peptides. In this review we provide an overview of the field to 2007 and we include both synthesis and design strategies required to produce useful RGD functional materials.

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Soft Matter

Production and performance of biomaterials containing RGD peptides

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