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Issue 5, 2008
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Controlling cell morphology on amino acid-modified cellulose

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Abstract

This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.

Graphical abstract: Controlling cell morphology on amino acid-modified cellulose

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Publication details

The article was received on 20 Dec 2007, accepted on 29 Feb 2008, published on 18 Mar 2008 and first published online on 18 Mar 2008


Article type: Paper
DOI: 10.1039/B719706N
Citation: Soft Matter, 2008,4, 1059-1065
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    Controlling cell morphology on amino acid-modified cellulose

    D. M. Kalaskar, J. E. Gough, R. V. Ulijn, W. W. Sampson, D. J. Scurr, F. J. Rutten, M. R. Alexander, C. L. R. Merry and S. J. Eichhorn, Soft Matter, 2008, 4, 1059
    DOI: 10.1039/B719706N

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