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Issue 6, 2008
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Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

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Abstract

Urocanic acid (UCA), produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR). Originally thought to be a ‘natural sunscreen’, studies conducted a quarter of a century ago proposed that UCA may be a chromophore for the immunosuppression that follows exposure to UVR. With its intriguing photochemistry, its role in immunosuppression and skin cancer development, and skin barrier function, UCA continues to be the subject of intense research effort. This review summarises the photochemical, photobiological and photoimmunological findings regarding UCA, published since 1998.

Graphical abstract: Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

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Publication details

The article was received on 12 Nov 2007, accepted on 22 Feb 2008 and first published on 13 Mar 2008


Article type: Perspective
DOI: 10.1039/B717398A
Citation: Photochem. Photobiol. Sci., 2008,7, 655-667
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    Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

    N. K. Gibbs, J. Tye and M. Norval, Photochem. Photobiol. Sci., 2008, 7, 655
    DOI: 10.1039/B717398A

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