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Issue 6, 2008
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Examination of the stability of hydrophobic (CdSe)ZnS quantum dots in the digestive tract of rats

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Abstract

Semiconductor quantum dots show promise as alternatives to organic dyes for biological labelling because of their bright and stable photoluminescence. The typical quantum dots is CdSe because colloidal synthesis for nanocrystals of this semiconductor is well established. CdSe is usually passivated with zinc sulfide. While the cytotoxicity of bulk CdSe is well documented, questions about (CdSe)ZnS potential toxicity and behaviour in vivo remain unanswered. The distribution and stability of (CdSe)ZnS quantum dots in Wistar line rats’ digestive tract were investigated. Hydrophobic quantum dots were mixed with fat or sonificated in water and administered orally. The distribution and stability of quantum dots moving through the digestive system of rats was followed by fluorescence spectroscopy. In both ways prepared quantum dots were degraded in the digestive tract of animals. Quantum dots mixed with fat were more stable and degraded more slowly than quantum dots sonificated in water. The data obtained suggest possible toxicity of (CdSe)ZnS quantum dots due to the liberation of Cd2+.

Graphical abstract: Examination of the stability of hydrophobic (CdSe)ZnS quantum dots in the digestive tract of rats

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Publication details

The article was received on 29 May 2007, accepted on 11 Oct 2007 and first published on 18 Apr 2008


Article type: Paper
DOI: 10.1039/B707920F
Citation: Photochem. Photobiol. Sci., 2008,7, 725-729
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    Examination of the stability of hydrophobic (CdSe)ZnS quantum dots in the digestive tract of rats

    V. Karabanovas, E. Zakarevicius, A. Sukackaite, G. Streckyte and R. Rotomskis, Photochem. Photobiol. Sci., 2008, 7, 725
    DOI: 10.1039/B707920F

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