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Volume 104, 2008
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Ion-channel engineering

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Abstract

The channel-mediated transport of ions through a membrane is of great importance in biological systems and holds a considerable potential for sensing applications. Ion-channel engineering follows two approaches. The first is the engineering of biological channels with the goal to control existing functionality. Currently, this area benefits from progress in structural information of ion channels, new methods in protein engineering (protein semi-synthesis), and the inclusion of chemical synthesis to obtain hybrid ion channels. The second approach in ion channel engineering is the de novo design. Here, progress emerges from self-assembly concepts to prepare β-barrel and π-barrel pores. This review focuses on contributions published in the year 2007 with inclusion of selected work of the time span 2005–2006.

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Publication details

The article was first published on 07 Mar 2008


Article type: Review Article
DOI: 10.1039/B703980H
Citation: Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 2008,104, 165-188
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    Ion-channel engineering

    L. Essen and U. Koert, Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 2008, 104, 165
    DOI: 10.1039/B703980H

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