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Issue 24, 2008
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Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates

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Abstract

A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.

Graphical abstract: Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates

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Publication details

The article was received on 11 Sep 2008, accepted on 02 Oct 2008 and first published on 17 Oct 2008


Article type: Communication
DOI: 10.1039/B815963G
Citation: Org. Biomol. Chem., 2008,6, 4494-4497
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    Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates

    B. Akagah, A. T. Lormier, A. Fournet and B. Figadère, Org. Biomol. Chem., 2008, 6, 4494
    DOI: 10.1039/B815963G

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