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Issue 20, 2008
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Synthetic and biological studies on the spiro-mamakone system

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Abstract

An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolitespiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure–activity profile for the natural product, establishing the importance of the enedione moiety to biological activity.

Graphical abstract: Synthetic and biological studies on the spiro-mamakone system

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The article was received on 17 Jul 2008, accepted on 05 Aug 2008 and first published on 03 Sep 2008


Article type: Paper
DOI: 10.1039/B812263F
Citation: Org. Biomol. Chem., 2008,6, 3854-3862
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    Synthetic and biological studies on the spiro-mamakone system

    A. C. Murphy, S. R. A. Devenish, A. C. Muscroft-Taylor, J. W. Blunt and M. H. G. Munro, Org. Biomol. Chem., 2008, 6, 3854
    DOI: 10.1039/B812263F

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