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Issue 18, 2008
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Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

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Abstract

The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

Graphical abstract: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

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Publication details

The article was received on 10 Jul 2008, accepted on 15 Jul 2008 and first published on 06 Aug 2008


Article type: Communication
DOI: 10.1039/B811797G
Citation: Org. Biomol. Chem., 2008,6, 3240-3243
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    Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

    T. Y. Zakharian, L. Di Costanzo and D. W. Christianson, Org. Biomol. Chem., 2008, 6, 3240
    DOI: 10.1039/B811797G

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