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Issue 20, 2008
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PNA based artificial nucleases displaying catalysis with turnover in the cleavage of a leukemia related RNA model

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Abstract

Several peptide nucleic acid based artificial nucleases (PNAzymes) are designed to create a bulge in the target RNA, which is a short model of the leukemia related bcr/abl mRNA. The target RNA is cleaved by the PNAzymes with a half-life of down to 11 h (using a 1 : 1 ratio of PNA-conjugate to target) and only upon base-pairing with the substrate. The PNA based systems are also shown to act in a catalytic fashion with turnover of substrate and are thus the first reported peptide nucleic acid based artificial RNA-cleaving enzymes.

Graphical abstract: PNA based artificial nucleases displaying catalysis with turnover in the cleavage of a leukemia related RNA model

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Publication details

The article was received on 16 Jun 2008, accepted on 16 Jul 2008 and first published on 20 Aug 2008


Article type: Paper
DOI: 10.1039/B810106J
Citation: Org. Biomol. Chem., 2008,6, 3837-3842
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    PNA based artificial nucleases displaying catalysis with turnover in the cleavage of a leukemia related RNA model

    M. Murtola and R. Strömberg, Org. Biomol. Chem., 2008, 6, 3837
    DOI: 10.1039/B810106J

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