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Issue 20, 2008
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Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

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Abstract

Fractionation of a cytotoxic extract obtained from a southern Australian marine sponge, Phorbas sp., yielded the known diterpenes phorbasins B–F (1–5) together with five new members of the phorbasin family, phorbasins G–K (6–10). Structures were assigned to the new phorbasins based on detailed spectroscopic analysis. A preliminary structure activity relationship (SAR) evaluation based on the co-metabolites phorbasins B–K (1–10) revealed aspects of the phorbasin pharmacophore.

Graphical abstract: Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

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Publication details

The article was received on 27 May 2008, accepted on 21 Jul 2008 and first published on 28 Aug 2008


Article type: Paper
DOI: 10.1039/B808866G
Citation: Org. Biomol. Chem., 2008,6, 3811-3815
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    Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

    H. Zhang, J. M. Major, R. J. Lewis and R. J. Capon, Org. Biomol. Chem., 2008, 6, 3811
    DOI: 10.1039/B808866G

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