The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry

Holly Schiltz; Mee-Kyung Chung; Stephen J. Lee; Michel R. Gagné

doi:10.1039/B808490D

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Organic & Biomolecular Chemistry

Issue 19, 2008

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The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry

Holly Schiltz , Mee-Kyung Chung , Stephen J. Lee and Michel R. Gagné

Org. Biomol. Chem., 2008, 6, 3597-3600

DOI: 10.1039/B808490D
Received 21 May 2008, Accepted 03 Jul 2008
First published on the web 06 Aug 2008

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Abstract
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Compounds
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Using mass spectrometry coupled with LC analysis we report evidence of diastereomer dependent fragmentation and oligomerization reactions in the ionization of acyl-hydrazone-based libraries of cyclic oligomers. These effects can significantly affect the accuracy of MS-based quantitations, but also provide a venue for examining ionization effects in dynamic combinatorial libraries (DCLs).

Abstract from Mass Spectrometry Bulletin 2009

Electrospray technique, Multiply charged ions, Quantitative organic analyses.

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Supplementary Info

Details of the HPLC-LP and UPLC-MS analyses, and selectedmass ion chromatograms for the dimers, trimers and tetramers in theDCL
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Organic & Biomolecular Chemistry

The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry

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