Synthesis and in vitro evaluation of imidazole-based wakayin analogues

Hung Hoang; Xiaofen Huang; Edward B. Skibo

doi:10.1039/B806883F

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Organic & Biomolecular Chemistry

Issue 17, 2008

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Synthesis and in vitro evaluation of imidazole-based wakayin analogues

Hung Hoang , Xiaofen Huang and Edward B. Skibo

Org. Biomol. Chem., 2008, 6, 3059-3064

DOI: 10.1039/B806883F
Received 25 Apr 2008, Accepted 01 Jul 2008
First published on the web 16 Jul 2008

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Analogues of wakayin based on diimidazo[1,5,4-de, 1,5,4-h]-quinoxaline have been prepared and evaluated with respect to cytostatic and cytotoxic activity. Assays in a 60-cell-line human cancer panel revealed selective activity against cells with the VEGF (Flt-1) receptor.

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Synthesis and in vitro evaluation of imidazole-based wakayin analogues

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