Epigenetic remodeling of the fungal secondary metabolome

Russell B. Williams; Jon C. Henrikson; Ashley R. Hoover; Andrlynn E. Lee; Robert H. Cichewicz

doi:10.1039/B804701D

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Organic & Biomolecular Chemistry

Issue 11, 2008

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Epigenetic remodeling of the fungal secondary metabolome

Russell B. Williams , Jon C. Henrikson , Ashley R. Hoover , Andrlynn E. Lee and Robert H. Cichewicz

Org. Biomol. Chem., 2008, 6, 1895-1897

DOI: 10.1039/B804701D
Received 19 Mar 2008, Accepted 04 Apr 2008
First published on the web 14 Apr 2008

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Compounds
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Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

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Experimental details, structure characterization, additional results with figures and tables
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Russell B. Williams
Jon C. Henrikson
Ashley R. Hoover
Andrlynn E. Lee
Robert H. Cichewicz

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Organic & Biomolecular Chemistry

Epigenetic remodeling of the fungal secondary metabolome

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