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Issue 11, 2008
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Epigenetic remodeling of the fungal secondary metabolome

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Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

Graphical abstract: Epigenetic remodeling of the fungal secondary metabolome

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Publication details

The article was received on 19 Mar 2008, accepted on 04 Apr 2008 and first published on 14 Apr 2008


Article type: Communication
DOI: 10.1039/B804701D
Citation: Org. Biomol. Chem., 2008,6, 1895-1897
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    Epigenetic remodeling of the fungal secondary metabolome

    R. B. Williams, J. C. Henrikson, A. R. Hoover, A. E. Lee and R. H. Cichewicz, Org. Biomol. Chem., 2008, 6, 1895
    DOI: 10.1039/B804701D

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