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Issue 15, 2008
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2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

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Abstract

2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofuran-3-ols were designed and synthesized by the allylations of benzoins followed by iodocyclization and nucleophilic replacement reactions with ethanthiol. These molecules exhibit IC50 for COX-2 at <10 nM concentration and exhibit average GI50 over all the 59 human tumor cell lines at μM concentration.

Graphical abstract: 2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

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Publication details

The article was received on 03 Mar 2008, accepted on 16 Apr 2008 and first published on 22 May 2008


Article type: Paper
DOI: 10.1039/B803608J
Citation: Org. Biomol. Chem., 2008,6, 2706-2712
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    2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

    P. Singh, A. Mittal, S. Kaur, W. Holzer and S. Kumar, Org. Biomol. Chem., 2008, 6, 2706
    DOI: 10.1039/B803608J

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