Jump to main content
Jump to site search

Issue 15, 2008
Previous Article Next Article

2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

Author affiliations

Abstract

2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofuran-3-ols were designed and synthesized by the allylations of benzoins followed by iodocyclization and nucleophilic replacement reactions with ethanthiol. These molecules exhibit IC50 for COX-2 at <10 nM concentration and exhibit average GI50 over all the 59 human tumor cell lines at μM concentration.

Graphical abstract: 2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Mar 2008, accepted on 16 Apr 2008 and first published on 22 May 2008


Article type: Paper
DOI: 10.1039/B803608J
Citation: Org. Biomol. Chem., 2008,6, 2706-2712
  •   Request permissions

    2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents

    P. Singh, A. Mittal, S. Kaur, W. Holzer and S. Kumar, Org. Biomol. Chem., 2008, 6, 2706
    DOI: 10.1039/B803608J

Search articles by author

Spotlight

Advertisements