Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura; Yu Tachikawa; Makoto Kitamura; Osamu Ohno; Masami Suganuma; Daisuke Uemura

doi:10.1039/B803107J

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Organic & Biomolecular Chemistry

Issue 12, 2008

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Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura , Yu Tachikawa , Makoto Kitamura , Osamu Ohno , Masami Suganuma and Daisuke Uemura

Org. Biomol. Chem., 2008, 6, 2058-2060

DOI: 10.1039/B803107J
Received 22 Feb 2008, Accepted 15 Apr 2008
First published on the web 24 Apr 2008

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The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

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¹H and ¹³C NMR data of complanine
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Kazuhiko Nakamura
Yu Tachikawa
Makoto Kitamura
Osamu Ohno
Masami Suganuma
Daisuke Uemura

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Organic & Biomolecular Chemistry

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

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