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Issue 11, 2008
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A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

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Abstract

We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a β-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.

Graphical abstract: A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

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Publication details

The article was received on 13 Feb 2008, accepted on 07 Mar 2008 and first published on 09 Apr 2008


Article type: Paper
DOI: 10.1039/B802470G
Citation: Org. Biomol. Chem., 2008,6, 1944-1948
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    A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

    Y. Lim, O. Kwon, E. Lee, P. Kim, C. Yun and M. Lee, Org. Biomol. Chem., 2008, 6, 1944
    DOI: 10.1039/B802470G

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