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Issue 13, 2008
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Cell-penetrating peptides as delivery vehicles for biology and medicine

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Abstract

Cell-penetrating peptides (CPPs) have found numerous applications in biology and medicine since the first synthetic cell-permeable sequence was identified two decades ago. Numerous types of drugs have been transported into cells using CPPs, including small-molecule pharmaceuticals, therapeutic proteins, and antisense oligonucleotides. Improved agents for medical imaging have been generated by conjugation with CPPs, with the appended peptides promoting cellular uptake and in some cases, cell-type specificity. Organelle-specific CPPs have also been generated, providing a means to target specific subcellular sites. This review highlights achievements in this area and illustrates the numerous examples where peptide chemistry was exploited as a means to provide new tools for biology and medicine.

Graphical abstract: Cell-penetrating peptides as delivery vehicles for biology and medicine

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Publication details

The article was received on 02 Jan 2008 and first published on 15 Apr 2008


Article type: Perspective
DOI: 10.1039/B719950C
Citation: Org. Biomol. Chem., 2008,6, 2242-2255
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    Cell-penetrating peptides as delivery vehicles for biology and medicine

    K. M. Stewart, K. L. Horton and S. O. Kelley, Org. Biomol. Chem., 2008, 6, 2242
    DOI: 10.1039/B719950C

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