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Issue 7, 2008
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Diversity-oriented synthesis; a spectrum of approaches and results

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Abstract

Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and in the identification of novel biologically active lead compounds, is also discussed.

Graphical abstract: Diversity-oriented synthesis; a spectrum of approaches and results

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Publication details

The article was received on 20 Dec 2007 and first published on 19 Feb 2008


Article type: Perspective
DOI: 10.1039/B719372F
Citation: Org. Biomol. Chem., 2008,6, 1149-1158
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    Diversity-oriented synthesis; a spectrum of approaches and results

    R. J. Spandl, A. Bender and D. R. Spring, Org. Biomol. Chem., 2008, 6, 1149
    DOI: 10.1039/B719372F

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