Issue 5, 2008
From the journal:

Organic & Biomolecular Chemistry

Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

Musa M. Musa,a   Karla I. Ziegelmann-Fjeld,b   Claire Vieilleb  and  Robert S. Phillips*ac  

* Corresponding authors

a Department of Chemistry, University of Georgia, Athens, Georgia 30602-2556, USA

b Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, USA

c Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-2556, USA
E-mail: rsphillips@chem.uga.edu
Fax: +1-706-542-9454
Tel: +1-706-542-1996

Abstract

The asymmetric reduction of hydrophobic phenyl-ring-containing ketones and the enantiospecific kinetic resolution of the corresponding racemic alcohols catalyzed by Thermoanaerobacter ethanolicus W110A secondary alcohol dehydrogenase were performed in mono- and biphasic systems containing either organic solvents or ionic liquids. Both yield and enantioselectivity for these transformations can be controlled by changing the reaction medium. The enzyme showed high tolerance to both water-miscible and -immiscible solvents, which allows biotransformations to be conducted at high substrate concentrations.

Graphical abstract: Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

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Article information

DOI
https://doi.org/10.1039/B717120J
Article type
Paper
Submitted
06 Nov 2007
Accepted
17 Dec 2007
First published
18 Jan 2008

Org. Biomol. Chem., 2008,6, 887-892

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Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

M. M. Musa, K. I. Ziegelmann-Fjeld, C. Vieille and R. S. Phillips, Org. Biomol. Chem., 2008, 6, 887 DOI: 10.1039/B717120J

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