Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

Musa M. Musa; Karla I. Ziegelmann-Fjeld; Claire Vieille; Robert S. Phillips

doi:10.1039/B717120J

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Organic & Biomolecular Chemistry

Issue 5, 2008

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Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

Musa M. Musa , Karla I. Ziegelmann-Fjeld , Claire Vieille and Robert S. Phillips

Org. Biomol. Chem., 2008, 6, 887-892

DOI: 10.1039/B717120J
Received 06 Nov 2007, Accepted 17 Dec 2007
First published on the web 18 Jan 2008

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The asymmetric reduction of hydrophobic phenyl-ring-containing ketones and the enantiospecific kinetic resolution of the corresponding racemic alcohols catalyzed by Thermoanaerobacter ethanolicus W110A secondary alcohol dehydrogenase were performed in mono- and biphasic systems containing either organic solvents or ionic liquids. Both yield and enantioselectivity for these transformations can be controlled by changing the reaction medium. The enzyme showed high tolerance to both water-miscible and -immiscible solvents, which allows biotransformations to be conducted at high substrate concentrations.

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Organic & Biomolecular Chemistry

Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

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