Natural products: chemical instruments to apprehend biological symphony

Mathieu Pucheault

doi:10.1039/B713022H

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Organic & Biomolecular Chemistry

Issue 3, 2008

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Natural products: chemical instruments to apprehend biological symphony

Mathieu Pucheault

Org. Biomol. Chem., 2008, 6, 424-432

DOI: 10.1039/B713022H
Received 23 Aug 2007, Accepted 29 Oct 2007
First published on the web 19 Nov 2007

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As a striking variety of biological activities are elicited by natural products, these chemicals have been used for decades to study biological phenomena. Understanding how these products interfere with normal cell functions at a molecular level led to a wide range of discoveries including new signaling pathways and proteins. Moreover, as natural products often act as chemical inhibitors, such studies often allow the identification of their binding partners as relevant targets for drug design. This article aims to emphasize how natural products or engineered analogs can be used as chemical tools to apprehend some biological problems from the point of view of a chemical biologist.

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