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Issue 1, 2008
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Efficient C2 functionalisation of 2H-2-imidazolines

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Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind–Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

Graphical abstract: Efficient C2 functionalisation of 2H-2-imidazolines

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Publication details

The article was received on 24 Aug 2007, accepted on 22 Oct 2007 and first published on 08 Nov 2007


Article type: Paper
DOI: 10.1039/B713065A
Citation: Org. Biomol. Chem., 2008,6, 130-137
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    Efficient C2 functionalisation of 2H-2-imidazolines

    R. S. Bon, N. E. Sprenkels, M. M. Koningstein, R. F. Schmitz, F. J. J. de Kanter, A. Dömling, M. B. Groen and R. V. A. Orru, Org. Biomol. Chem., 2008, 6, 130
    DOI: 10.1039/B713065A

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