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Issue 1, 2008
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Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

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Abstract

Phenothiazine can be incorporated as a redox-active probe into DNA in two conceptually different ways: the non-nucleosidic DNA base surrogate exhibits similar properties to 10-methylphenothiazine but with no preferential base-pairing properties, whereas the phenothiazine-modified uridine has different optical and electrochemical properties, but exhibits preferred Watson–Crick base pairing with adenine.

Graphical abstract: Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

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Publication details

The article was received on 12 Jun 2007, accepted on 22 Oct 2007 and first published on 31 Oct 2007


Article type: Communication
DOI: 10.1039/B708904J
Citation: Org. Biomol. Chem., 2008,6, 48-50
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    Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

    C. Wagner and H. Wagenknecht, Org. Biomol. Chem., 2008, 6, 48
    DOI: 10.1039/B708904J

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