Isoprenoid-like alkylations in polyketide biosynthesis

Christopher T. Calderone

doi:10.1039/B807243D

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Natural Product Reports

Issue 5, 2008

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Isoprenoid-like alkylations in polyketide biosynthesis

Christopher T. Calderone

Nat. Prod. Rep., 2008, 25, 845-853

DOI: 10.1039/B807243D
Received 01 May 2008, First published on the web 18 Jun 2008

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Polyketides are secondary metabolites biosynthesized by the iterative Claisen condensation of malonate units. Despite utilizing only a small set of biochemical transformations, the polyketide biosynthetic machinery yields products of striking structural complexity and diversity. Recently, a new polyketide alkylation pathway was characterized that allows access to “β-branched” structures. This Highlight will describe this alkylation sequence, with special emphasis on its parallels to isoprenoid biosynthesis from primary metabolism and the scope of structures accessible via this pathway.

Abstract from Natural Product Updates 2009

A review, with 33 references, discussing the new polyketide alkylation pathway that allows access to β-branched structures, with emphasis on its similarity to isoprenoid biosynthesis and the scope of structures accessible using the pathway.

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Isoprenoid-like alkylations in polyketide biosynthesis

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