Jump to main content
Jump to site search

Issue 12, 2008
Previous Article Next Article

Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(II), Pd(II) and Cu(II) complexes with pyridine-pyrazoles derivatives

Author affiliations

Abstract

The synthesis, structure and cytotoxic activity of Pt(II), Pd(II) and Cu(II) complexes of the general formula MLCl2 (M = Pt, Pd, Cu) 2–4 and (CuLCl2)25 where L is pyrazole-based chelate ligand 3-methyl-1-(2-pyridinyl)-1H-chromene[4,3-c]pyrazol-4-one 1 are described. The complexes were characterized by elemental analysis, infrared and 1H NMR spectroscopy, as well as electrospray mass spectrometry. Compounds 3 and 5 were also studied using X-ray diffraction. In addition, geometries, partial atomic charges, and lipophilicity, which determines their ability to penetrate through cells membranes, were obtained computationally. Complexes 2–4 exhibit square-planar geometries around the metal(II) centers and adopt cis configuration. Complex 5 is a dimer with distorted tetragonal pyramidal configuration at both Cu(II) centers, which are connected by two μ2-chloro bridges in axial positions. The cytotoxic effect of these complexes was examined on HL-60 and NALM-6 human leukemia cells and melanoma WM-115 cells. The Pt-complex cis-2 exhibited moderate cytotoxic activity against leukemic cells, but relatively high activity toward melanoma cells with cytotoxicity of IC50 = 16.6 μM at a level comparable to that of cisplatin (18.2 μM).

Graphical abstract: Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(ii), Pd(ii) and Cu(ii) complexes with pyridine-pyrazoles derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 May 2008, accepted on 01 Jul 2008 and first published on 10 Sep 2008


Article type: Paper
DOI: 10.1039/B808301K
Citation: New J. Chem., 2008,32, 2238-2244
  •   Request permissions

    Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(II), Pd(II) and Cu(II) complexes with pyridine-pyrazoles derivatives

    E. Budzisz, I. Lorenz, P. Mayer, P. Paneth, L. Szatkowski, U. Krajewska, M. Rozalski and M. Miernicka, New J. Chem., 2008, 32, 2238
    DOI: 10.1039/B808301K

Search articles by author

Spotlight

Advertisements