Combination dual responsive polypeptide vectors for enhanced gene delivery

Rujikan Nasanit; Parvez Iqbal; Mahmoud Soliman; Neil Spencer; Stephanie Allen; Martyn C. Davies; Simon S. Briggs; Leonard W. Seymour; Jon A. Preece; Cameron Alexander

doi:10.1039/B803262A

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Molecular BioSystems

Issue 7, 2008

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Combination dual responsive polypeptide vectors for enhanced gene delivery

Rujikan Nasanit , Parvez Iqbal , Mahmoud Soliman , Neil Spencer , Stephanie Allen , Martyn C. Davies , Simon S. Briggs , Leonard W. Seymour , Jon A. Preece and Cameron Alexander

Mol. BioSyst., 2008, 4, 741-745

DOI: 10.1039/B803262A
Received 25 Feb 2008, Accepted 07 Apr 2008
First published on the web 08 May 2008

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Abstract
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Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK_a vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK_a analogues.

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Molecular BioSystems

Combination dual responsive polypeptide vectors for enhanced gene delivery

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