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Issue 7, 2008
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Deciphering the glycosaminoglycan code with the help of microarrays

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Abstract

Carbohydrate microarrays have become a powerful tool to elucidate the biological role of complex sugars. Microarrays are particularly useful for the study of glycosaminoglycans (GAGs), a key class of carbohydrates. The high-throughput chip format enables rapid screening of large numbers of potential GAG sequences produced via a complex biosynthesis while consuming very little sample. Here, we briefly highlight the most recent advances involving GAG microarrays built with synthetic or naturally derived oligosaccharides. These chips are powerful tools for characterizing GAGprotein interactions and determining structure–activity relationships for specific sequences. Thereby, they contribute to decoding the information contained in specific GAG sequences.

Graphical abstract: Deciphering the glycosaminoglycan code with the help of microarrays

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Publication details

The article was first published on 23 May 2008


Article type: Highlight
DOI: 10.1039/B802217H
Citation: Mol. BioSyst., 2008,4, 707-711
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    Deciphering the glycosaminoglycan code with the help of microarrays

    J. L. de Paz and P. H. Seeberger, Mol. BioSyst., 2008, 4, 707
    DOI: 10.1039/B802217H

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