Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

Young Jin Lee

doi:10.1039/B801810C

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Molecular BioSystems

Issue 8, 2008

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Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

Young Jin Lee

Mol. BioSyst., 2008, 4, 816-823

DOI: 10.1039/B801810C
Received 01 Feb 2008, Accepted 14 Apr 2008
First published on the web 10 Jun 2008

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Mass spectrometry has become the method of choice to detect and quantify the minute amounts of proteins at the genomic scale. It has recently been adopted for three dimensional structure analyses of proteins or protein complexes by chemically cross-linking their intact forms and analyzing the cross-linked pieces after digestion. This highlight provides an overview of the technology with a focus on advances in the last two years. This cross-linking mass spectrometry has a great potential to become a powerful tool to supplement current X-ray and NMR method of protein structure analysis.

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Molecular BioSystems

Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

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