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Issue 8, 2008
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Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

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Abstract

Mass spectrometry has become the method of choice to detect and quantify the minute amounts of proteins at the genomic scale. It has recently been adopted for three dimensional structure analyses of proteins or protein complexes by chemically cross-linking their intact forms and analyzing the cross-linked pieces after digestion. This highlight provides an overview of the technology with a focus on advances in the last two years. This cross-linking mass spectrometry has a great potential to become a powerful tool to supplement current X-ray and NMR method of protein structure analysis.

Graphical abstract: Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

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Publication details

The article was received on 01 Feb 2008, accepted on 14 Apr 2008 and first published on 10 Jun 2008


Article type: Review Article
DOI: 10.1039/B801810C
Citation: Mol. BioSyst., 2008,4, 816-823
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    Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

    Y. Jin Lee, Mol. BioSyst., 2008, 4, 816
    DOI: 10.1039/B801810C

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