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Issue 6, 2008
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Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

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Abstract

A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.

Graphical abstract: Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

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Publication details

The article was received on 03 Jan 2008, accepted on 27 Mar 2008 and first published on 15 Apr 2008


Article type: Paper
DOI: 10.1039/B719782A
Citation: Mol. BioSyst., 2008,4, 532-541
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    Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

    J. B. Wong, S. Grosse, A. B. Tabor, S. L. Hart and H. C. Hailes, Mol. BioSyst., 2008, 4, 532
    DOI: 10.1039/B719782A

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