Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

John B. Wong; Stephanie Grosse; Alethea B. Tabor; Stephen L. Hart; Helen C. Hailes

doi:10.1039/B719782A

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Molecular BioSystems

Issue 6, 2008

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Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

John B. Wong , Stephanie Grosse , Alethea B. Tabor , Stephen L. Hart and Helen C. Hailes

Mol. BioSyst., 2008, 4, 532-541

DOI: 10.1039/B719782A
Received 03 Jan 2008, Accepted 27 Mar 2008
First published on the web 15 Apr 2008

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Abstract
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A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.

Supplementary Info

Performance of lipids 19–25 compared to Lipofectin™ ( 1 and 2) in lipopolyplex formulations for 16HBE14o-, bEND.3 or PVSMCs cell lines
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John B. Wong
Stephanie Grosse
Alethea B. Tabor
Stephen L. Hart
Helen C. Hailes

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Molecular BioSystems

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

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