A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

Irene Kiburu; Andrew Shurer; Lei Yan; Herman O. Sintim

doi:10.1039/B719423D

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Molecular BioSystems

Issue 6, 2008

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A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

Irene Kiburu , Andrew Shurer , Lei Yan and Herman O. Sintim

Mol. BioSyst., 2008, 4, 518-520

DOI: 10.1039/B719423D
Received 03 Jan 2008, Accepted 21 Apr 2008
First published on the web 29 Apr 2008

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Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

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Molecular BioSystems

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

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