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Issue 5, 2008
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Signal transduction pathways used by NLR-type innate immune receptors

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Abstract

Proteins from the nucleotide-binding domain, LRR containing (NLR) family are involved in sensing bacterial invasion and danger signals in mammalian cells. Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens. Recent data now shed light on the signal transduction pathways used by NLR proteins. This review summarizes advances in our understanding of signalling through NLRs with special emphasis on the Nod1 and Nod2 pathways.

Graphical abstract: Signal transduction pathways used by NLR-type innate immune receptors

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Publication details

The article was first published on 27 Mar 2008


Article type: Highlight
DOI: 10.1039/B718948F
Citation: Mol. BioSyst., 2008,4, 380-386
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    Signal transduction pathways used by NLR-type innate immune receptors

    T. A. Kufer, Mol. BioSyst., 2008, 4, 380
    DOI: 10.1039/B718948F

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