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Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.

Review Article

Mismatch formation in solution and on DNA microarrays: how modified nucleosides can overcome shortcomings of imperfect hybridization caused by oligonucleotide composition and base pairing

Frank Seela*a and   Simone Budowa  
Corresponding authors
Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, 48149 Münster, Germany and Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastraße 7, 49069 Osnabrück, Germany
E-mail: Frank.Seela@uni-osnabrueck.de, Seela@uni-muenster.de
Fax: +49(0)251 53406 857
Tel: +49(0)251 53406 500
Mol. BioSyst., 2008,4, 232-245

DOI: 10.1039/B713259J
Received 29 Aug 2007, Accepted 02 Jan 2008
First published online 04 Feb 2008
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