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Issue 1, 2008
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Systematic screens for human disease genes, from yeast to human and back

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Abstract

Systematic screens for human disease genes have emerged in recent years, due to the wealth of information provided by genome sequences and large scale datasets. Here we review how integration of genomic data in yeast and human is helping to elucidate the genetic basis of mitochondrial diseases. The identification of nearly all yeast mitochondrial proteins and many of their functional interactions provides insight into the role of mitochondria in cellular processes. This information enables prioritization of the candidate genes underlying mitochondrial disorders. In an iterative fashion, the link between predicted human candidate genes and their disease phenotypes can be experimentally tested back in yeast.

Graphical abstract: Systematic screens for human disease genes, from yeast to human and back

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Publication details

The article was received on 22 Jun 2007, accepted on 23 Aug 2007 and first published on 25 Sep 2007


Article type: Highlight
DOI: 10.1039/B709494A
Citation: Mol. BioSyst., 2008,4, 18-29
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    Systematic screens for human disease genes, from yeast to human and back

    F. Perocchi, E. Mancera and L. M. Steinmetz, Mol. BioSyst., 2008, 4, 18
    DOI: 10.1039/B709494A

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