An active bubble trap and debubbler for microfluidic systems

Alison M. Skelley; Joel Voldman

doi:10.1039/B807037G

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Lab on a Chip

Issue 10, 2008

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An active bubble trap and debubbler for microfluidic systems

Alison M. Skelley and Joel Voldman

Lab Chip, 2008, 8, 1733-1737

DOI: 10.1039/B807037G
Received 29 Apr 2008, Accepted 16 Jul 2008
First published on the web 28 Aug 2008

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We present a novel, fully integrated microfluidic bubble trap and debubbler. The 2-layer structure, based on a PDMS valve design, utilizes a featured membrane to stop bubble progression through the device. A pneumatic chamber directly above the trap is evacuated, and the bubble is pulled out through the gas-permeable PDMS membrane. Normal device operation, including continuous flow at atmospheric pressure, is maintained during the entire trapping and debubbling process. We present a range of trap sizes, from 2 to 10 mm diameter, and can trap and remove bubbles up to 25 μL in under 3 h.

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