Controlled encapsulation of single-cells into monodisperse picolitre drops

Jon F. Edd; Dino Di Carlo; Katherine J. Humphry; Sarah Köster; Daniel Irimia; David A. Weitz; Mehmet Toner

doi:10.1039/B805456H

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Lab on a Chip

Issue 8, 2008

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Controlled encapsulation of single-cells into monodisperse picolitre drops

Jon F. Edd , Dino Di Carlo , Katherine J. Humphry , Sarah Köster , Daniel Irimia , David A. Weitz and Mehmet Toner

Lab Chip, 2008, 8, 1262-1264

DOI: 10.1039/B805456H
Received 02 Apr 2008, Accepted 03 Jun 2008
First published on the web 13 Jun 2008

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Abstract
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Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation.

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Articles By

Jon F. Edd
Dino Di Carlo
Katherine J. Humphry
Sarah Köster
Daniel Irimia
David A. Weitz
Mehmet Toner

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Lab on a Chip

Controlled encapsulation of single-cells into monodisperse picolitre drops

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