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Issue 8, 2008
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Controlled encapsulation of single-cells into monodisperse picolitre drops

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Abstract

Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation.

Graphical abstract: Controlled encapsulation of single-cells into monodisperse picolitre drops

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Publication details

The article was received on 02 Apr 2008, accepted on 03 Jun 2008 and first published on 13 Jun 2008


Article type: Communication
DOI: 10.1039/B805456H
Citation: Lab Chip, 2008,8, 1262-1264
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    Controlled encapsulation of single-cells into monodisperse picolitre drops

    J. F. Edd, D. Di Carlo, K. J. Humphry, S. Köster, D. Irimia, D. A. Weitz and M. Toner, Lab Chip, 2008, 8, 1262
    DOI: 10.1039/B805456H

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