Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

Fei Zeng; Christopher B. Rohde; Mehmet Fatih Yanik

doi:10.1039/B804808H

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Lab on a Chip

Issue 5, 2008

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Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

Fei Zeng , Christopher B. Rohde and Mehmet Fatih Yanik

Lab Chip, 2008, 8, 653-656

DOI: 10.1039/B804808H
Received 20 Mar 2008, Accepted 28 Mar 2008
First published on the web 02 Apr 2008

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Techniques for stable, rapid and repeatable small-animal immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multi-cellular organisms. We demonstrate a method for non-invasive and high-throughput on-chip immobilization of physiologically active C. elegans without the use of anesthesia or cooling, but with comparable stability even for the most demanding purposes. We show observation and manipulation of sub-cellular features in immobilized animals using two-photon microscopy and femtosecond-laser microsurgery.

Abstract from Analytical Abstracts 2008

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Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

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