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Issue 7, 2008
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Stop-flow lithography to generate cell-laden microgel particles

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Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, the fabrication of large numbers of cell-laden microgel particles using a continuous microfluidic process called stop-flow lithography (SFL). Prepolymer solution containing cells was flowed through a microfluidic device and arrays of individual particles were repeatedly defined using pulses of UV light through a transparency mask. Unlike photolithography, SFL can be used to synthesize microgel particles continuously while maintaining control over particle size, shape and anisotropy. Therefore, SFL may become a useful tool for generating cell-laden microgels for various biomedical applications.

Graphical abstract: Stop-flow lithography to generate cell-laden microgel particles

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Publication details

The article was received on 11 Mar 2008, accepted on 24 Apr 2008 and first published on 22 May 2008

Article type: Paper
DOI: 10.1039/B804234A
Citation: Lab Chip, 2008,8, 1056-1061
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    Stop-flow lithography to generate cell-laden microgel particles

    P. Panda, S. Ali, E. Lo, B. G. Chung, T. A. Hatton, A. Khademhosseini and P. S. Doyle, Lab Chip, 2008, 8, 1056
    DOI: 10.1039/B804234A

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